منابع مشابه
Cidofovir Activity against Poxvirus Infections
Cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, HPMPC] is an acyclic nucleoside analog approved since 1996 for clinical use in the treatment of cytomegalovirus (CMV) retinitis in AIDS patients. Cidofovir (CDV) has broad-spectrum activity against DNA viruses, including herpes-, adeno-, polyoma-, papilloma- and poxviruses. Among poxviruses, cidofovir has shown in vitro activity ag...
متن کاملModélisation du déroulement d'activités humaines en mer côtière. Scénarios appliqués à la mer d'Iroise
Coastal seas, marine part of the coastal zone, are particulary attractive for human society. Human activities involve interactions that can lead to conflicts and to ressources degradation. In order to analyse the coastal system, the Geomer laboratory has developed a modelling platform of Human Activities Dynamic (DAHU) which contains a specific module adapted to the human marine activities (DAH...
متن کاملDevelopment of CMX001 for the Treatment of Poxvirus Infections
CMX001 (phosphonic acid, [[(S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]mono[3-(hexadecyloxy)propyl] ester) is a lipid conjugate of the acyclic nucleotide phosphonate, cidofovir (CDV). CMX001 is currently in Phase II clinical trials for the prophylaxis of human cytomegalovirus infection and under development using the Animal Rule for smallpox infection. It has proven e...
متن کاملExtracellular Virions: The Advance Guard of Poxvirus Infections
Most poxviruses produce multiple types of virions: intracellular mature virions (MVs), wrapped virions (WVs), and extracellular virions (EVs). The EVs represent the culmination of a morphogenetic pathway including the development of MVs, which are then transformed into WVs, and finally transformed into EVs. Each EV consists of one form of MV wrapped within a second lipid membrane containing at ...
متن کاملCross-Neutralizing and Protective Human Antibody Specificities to Poxvirus Infections
Monkeypox (MPXV) and cowpox (CPXV) are emerging agents that cause severe human infections on an intermittent basis, and variola virus (VARV) has potential for use as an agent of bioterror. Vaccinia immune globulin (VIG) has been used therapeutically to treat severe orthopoxvirus infections but is in short supply. We generated a large panel of orthopoxvirus-specific human monoclonal antibodies (...
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ژورنال
عنوان ژورنال: Annales de Dermatologie et de Vénéréologie
سال: 2019
ISSN: 0151-9638
DOI: 10.1016/j.annder.2019.03.001